The effect of the supernatant of the thymic epithelial cell line, IT-45R1 (STEL), on thymocyte reactivity to mitogens

S. Kasahara, T. Itoh, T. Mori

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The supernatant of the thymic epithelial cell line, IT-45R1 (STEL), previously proven to induce the differentiation of T-lymphocyte progenitors in the rat bone marrow, was examined for its influence on the differentiation of rat thymocytes. Preincubation with STEL increased the reactivity of rat thymocytes to Con A and PHA. The effect of STEL was found to be significant within a wide range of STEL dilution even at 1:1000, but not at 1:10000, showing dose-dependency of this effect. It took about 24 h for STEL to increase the responses of thymocytes to Con A and PHA. From these results, it is concluded that STEL could also induce the differentiation of rat thymocytes.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalThymus
Volume5
Issue number2
Publication statusPublished - 1983 Jan 1

ASJC Scopus subject areas

  • Immunology

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