The effect of taurine on the salt-dependent blood pressure increase in the voltage-dependent calcium channel β3-subunit-deficient mouse

Kunie Hagiwara, Gorou Kuroki, Pei Xiang Yuan, Takashi Suzuki, Manabu Murakami, Takuzou Hano, Hironobu Sasano, Teruyuki Yanagisawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To examine the anti-hypertensive effect of taurine, we studied the effects of taurine on the salt-dependent blood pressure elevation, the electrocardiogram, and plasma catecholamine levels in the voltage-dependent calcium channel β3-subunit-deficient mouse. In the wild-type mice, chronic high-salt loading (8% NaCl in chow) did not increase the blood pressure, whereas there was a significant increase in the systolic blood pressure in the β3-subunit-deficient mice given a high-salt diet. Oral supplementation of taurine (3% in drinking water) could attenuate the increase in the blood pressure elicited by the high-salt diet. Plasma catecholamine levels were significantly decreased by the high-salt diet, and supplementation of taurine prevented those decreases in β3-subunit-deficient mice. It is suggested, therefore, that chronic supplementation of taurine has an anti-hypertensive action in salt-dependent blood pressure elevation.

Original languageEnglish
Pages (from-to)S127-S131
JournalJournal of Cardiovascular Pharmacology
Volume41
Issue numberSUPPL. 1
Publication statusPublished - 2003 Jan 1

Keywords

  • Blood pressure
  • Calcium channels
  • Catecholamine
  • Electrocardiogram
  • Taurine

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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