The Effect of Protamine on Serum Complement Activity in Aminonucleoside Nephropathy

Kazuo Fukuda, Jin Seino, Takao Saito, Kei Yamakage, Yoshio Kyogoku, Kosei Kurosawa, Hiroshi Sato, Takashi Furuyama, Kaoru Yoshinaga

Research output: Contribution to journalArticle

Abstract

Fukuda, K., Seino, J., Saito, T., Yamakage, K., Kyogoku, Y., Kurosawa, K, Sato, H., Furuyama, T. and Yoshinaga, K. The Effect of Protamine on Serum Complement Activity in Aminonucleoside Nephropathy. Tohoku J. exp. Med., 1984, 143 (3), 315-318-Combined administration of protamine sulfate (Ps) and aminonucleoside (AN) to rats causes severe nephrotic syndrome and, histologically, focal glomerular sclerosis. These changes are more distinct than those produced by AN alone. While the exact mechanism of Ps acting on AN nephropathy is not known, marked hypocomplementemia was observed regularly after the Ps +AN injection, suggeting that complement is activated and consumed in the kidney. It is suggested that complement may play an important role in AN + Ps nephropathy. -aminonucleoside; protamine; complement.

Original languageEnglish
Pages (from-to)315-318
Number of pages4
JournalTohoku Journal of Experimental Medicine
Volume143
Issue number3
DOIs
Publication statusPublished - 1984 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'The Effect of Protamine on Serum Complement Activity in Aminonucleoside Nephropathy'. Together they form a unique fingerprint.

  • Cite this

    Fukuda, K., Seino, J., Saito, T., Yamakage, K., Kyogoku, Y., Kurosawa, K., Sato, H., Furuyama, T., & Yoshinaga, K. (1984). The Effect of Protamine on Serum Complement Activity in Aminonucleoside Nephropathy. Tohoku Journal of Experimental Medicine, 143(3), 315-318. https://doi.org/10.1620/tjem.143.315