The effect of molecular structure on the anticancer drug release rate from prodrug nanoparticles

Yoshikazu Ikuta; Yoshitaka Koseki; Tsunenobu Onodera; Hidetoshi Oikawa; Hitoshi Kasai

doi:10.1039/c5cc04164c

The effect of molecular structure on the anticancer drug release rate from prodrug nanoparticles

Yoshikazu Ikuta, Yoshitaka Koseki, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

Materials-Measurement Hybrid Research Center

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The controlled release of an anticancer agent from drug nanoparticles could be achieved by varying the linker length of dimeric compounds as prodrug. Notably, the cytotoxicity of the cancer cells was closely related to the release rate of drug compounds. This strategy will lead to the establishment of the novel delivery system using drug nanoparticles.

Original language	English
Pages (from-to)	12835-12838
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	64
DOIs	https://doi.org/10.1039/c5cc04164c
Publication status	Published - 2015 Aug 18

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c5cc04164c

Cite this

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abstract = "The controlled release of an anticancer agent from drug nanoparticles could be achieved by varying the linker length of dimeric compounds as prodrug. Notably, the cytotoxicity of the cancer cells was closely related to the release rate of drug compounds. This strategy will lead to the establishment of the novel delivery system using drug nanoparticles.",

author = "Yoshikazu Ikuta and Yoshitaka Koseki and Tsunenobu Onodera and Hidetoshi Oikawa and Hitoshi Kasai",

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AU - Koseki, Yoshitaka

AU - Onodera, Tsunenobu

AU - Oikawa, Hidetoshi

AU - Kasai, Hitoshi

PY - 2015/8/18

Y1 - 2015/8/18

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The effect of molecular structure on the anticancer drug release rate from prodrug nanoparticles

Abstract

ASJC Scopus subject areas

UN SDGs

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