The effect of low temperatures on environmental radiation damage in living systems: Does hypothermia show promise for space travel?

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Low-temperature treatments (i.e., hypothermia) may be one way of regulating environmental radiation damage in living systems. With this in mind, hibernation under hypothermic conditions has been proposed as a useful approach for long-term human space flight. However, the underlying mechanisms of hypothermia-induced radioresistance are as yet undetermined, and the conventional risk assessment of radiation exposure during hibernation remains insufficient for estimating the effects of chronic exposure to galactic cosmic rays (GCRs). To promote scientific discussions on the application of hibernation in space travel, this literature review provides an overview of the progress to date in the interdisciplinary research field of radiation biology and hypothermia and addresses possible issues related to hypothermic treatments as countermeasures against GCRs. At present, there are concerns about the potential effects of chronic radiation exposure on neurological disorders, carcinogenesis, ischemia heat failures, and infertility in astronauts; these require further study. These concerns may be resolved by comparing and integrating data gleaned from experimental and epidemiological studies.

Original languageEnglish
Article number6349
Pages (from-to)1-11
Number of pages11
JournalInternational journal of molecular sciences
Volume21
Issue number17
DOIs
Publication statusPublished - 2020 Sep 1

Keywords

  • Environmental radiation
  • HIF-1
  • Hibernation
  • Hypothermia
  • Hypoxia
  • ROS
  • Radioresistance
  • Space travel

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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