The effect of long-term post-ischemic bifemelane hydrochloride treatment on cholinergic systems in the gerbil hippocampus

Yi Lin Huang, Hiroshi Onodera, Atsushi Takeda, Yasuto Itoyama, Kyuya Kogure

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Bifemelane hydrochloride (BF) is a modulator of various neurotransmitter systems. The effect of BF on the cholinergic system was studied in the gerbil hippocampus at 100 days after ischemic damage. Marked enhancement of AChE staining was noticed in the CA1 of saline-treated animals at 100 days after ischemia, while the post-ischemic enhancement of AChE staining intensity was milder in BF-treated animals. Muscarinic receptor density was markedly decreased in the CA1 subfield after ischemia. Interestingly, BF-treated animals showed higher muscarinic receptor binding in many brain areas, particularly in the dentate gyrus. These results indicate that BF modulates cholinergic neuronal plasticity in the ischemic hippocampus after long-term survival.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalBrain research
Volume722
Issue number1-2
DOIs
Publication statusPublished - 1996 May 25

Keywords

  • acetylcholinesterase
  • hippocampus
  • ischemia
  • muscarinic receptor
  • synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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