The effect of liver hydrolysate on chronic ethanol-induced hepatic injury in normal rats

Kotaro Yamada, Kazuma Ueda, Hitoshi Shirakawa, Puspo Edi Giriwono, Satoru Honda, Hidetomo Sakurai, Michio Komai

Research output: Contribution to journalArticle

Abstract

The mechanism underlying the improvement in hepatic function by liver hydrolysate (LH) after ethanol-induced hepatic injury is unclear. Therefore, we investigated the effects of LH administration on chronic ethanol-induced hepatic injury in normal rats and the mechanism underlying the improvement of its symptoms by LH. LH attenuated liver damage and reduced oxidative stress after chronic ethanol-induced hepatic injury in normal rats. LH treatment reduced hepatic injury biomarkers of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). LH treatment also decreased levels of 8-hydroxy-deoxyguanosine (8-OHdG) as oxidative stress marker. LH may prove beneficial to prevent the liver damage of chronic ethanol, at least in part, by alleviating oxidative stress.

Original languageEnglish
Pages (from-to)554-557
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume43
Issue number3
DOIs
Publication statusPublished - 2020 Mar 1

Keywords

  • Chronic ethanol
  • Liver damage
  • Liver hydrolysate
  • Oxidative stress

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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