The effect of liver hydrolysate on chronic ethanol-induced hepatic injury in normal rats

Kotaro Yamada, Kazuma Ueda, Hitoshi Shirakawa, Puspo Edi Giriwono, Satoru Honda, Hidetomo Sakurai, Michio Komai

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    The mechanism underlying the improvement in hepatic function by liver hydrolysate (LH) after ethanol-induced hepatic injury is unclear. Therefore, we investigated the effects of LH administration on chronic ethanol-induced hepatic injury in normal rats and the mechanism underlying the improvement of its symptoms by LH. LH attenuated liver damage and reduced oxidative stress after chronic ethanol-induced hepatic injury in normal rats. LH treatment reduced hepatic injury biomarkers of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). LH treatment also decreased levels of 8-hydroxy-deoxyguanosine (8-OHdG) as oxidative stress marker. LH may prove beneficial to prevent the liver damage of chronic ethanol, at least in part, by alleviating oxidative stress.

    Original languageEnglish
    Pages (from-to)554-557
    Number of pages4
    JournalBiological and Pharmaceutical Bulletin
    Volume43
    Issue number3
    DOIs
    Publication statusPublished - 2020 Mar 1

    Keywords

    • Chronic ethanol
    • Liver damage
    • Liver hydrolysate
    • Oxidative stress

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmaceutical Science

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