The effect of lactogenic hormones on protein synthesis and amino acid uptake in rat mammary acinar cell culture at various physiological stages

S. G. Roh, M. G. Baik, Y. J. Choi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

1. 1. The activities of protein synthesis and amino acid uptake at various physiological stages were determined by the incorporation of radioactive materials ([3H]-lysine, [14C]-cycloleucine) in rat mammary epithelial cell cultures. The activity of protein synthesis and amino acid uptake was higher in early lactation than in virgin, pregnant and late lactation stages. 2. 2. Lactogenic hormones (prolactin, hydrocortisone and insulin) treatment related with mammary growth and differentiation increased the activities of protein synthesis and amino acid uptake. But increase of these activities was different at each physiological stage. 3. 3. The effect of prolactin and hydrocortisone on the activities were greater in virgin, pregnant and late lactation than in early lactation. And effect of insulin was greater in pregnant and early lactation than in virgin and weanling.

Original languageEnglish
Pages (from-to)479-485
Number of pages7
JournalInternational Journal of Biochemistry
Volume26
Issue number4
DOIs
Publication statusPublished - 1994 Apr
Externally publishedYes

Keywords

  • Rat Mammary acinar cell culture Protein synthesis Amino acid uptake Lactogenic hormones

ASJC Scopus subject areas

  • Biochemistry

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