TY - JOUR
T1 - The effect of graded calcium infusions on rhythmic blood pressure oscillations in normal man
AU - Munakata, Masanori
AU - Imai, Yutaka
AU - Mizunashi, Kazutoshi
AU - Hashimoto, Junichiro
AU - Sekino, Hiroshi
AU - Furukawa, Yotaro
AU - Abe, Keishi
PY - 1995/2
Y1 - 1995/2
N2 - This study was designed to determine whether calcium contributes to the regulation of rhythmic oscillations in blood pressure. Six normal subjects received sequential 1-h infusions of calcium gluconate (1.5, 3.0 and 4.5 mg calcium/kg/h) during continuous blood pressure (Finapres) monitoring. The plasma ionized calcium ([Ca2+]) concentration increased from 4.6 ± 0.07 mg/dl to 5.97 ± 0.20 mg/dl (p < 0.01) with infusion. The mid-frequency (0.07-0.14 Hz, Mayer wave) power spectrum of diastolic blood pressure was depressed slightly following the first dose but increased significantly following the final dose (p < 0.05). The high-frequency (0.15-0.40 Hz) power spectrum of systolic blood pressure decreased following the first dose (p < 0.05) and subsequently remained low. The low-frequency (0.02-0.06 Hz) power spectrum was not affected. These results demonstrate that graded hypercalcaemia affects blood pressure oscillations in man. Our data suggest that the amplitude of the Mayer wave, a clinical marker of sympathetic vascular tone, is modulated in part by calcium.
AB - This study was designed to determine whether calcium contributes to the regulation of rhythmic oscillations in blood pressure. Six normal subjects received sequential 1-h infusions of calcium gluconate (1.5, 3.0 and 4.5 mg calcium/kg/h) during continuous blood pressure (Finapres) monitoring. The plasma ionized calcium ([Ca2+]) concentration increased from 4.6 ± 0.07 mg/dl to 5.97 ± 0.20 mg/dl (p < 0.01) with infusion. The mid-frequency (0.07-0.14 Hz, Mayer wave) power spectrum of diastolic blood pressure was depressed slightly following the first dose but increased significantly following the final dose (p < 0.05). The high-frequency (0.15-0.40 Hz) power spectrum of systolic blood pressure decreased following the first dose (p < 0.05) and subsequently remained low. The low-frequency (0.02-0.06 Hz) power spectrum was not affected. These results demonstrate that graded hypercalcaemia affects blood pressure oscillations in man. Our data suggest that the amplitude of the Mayer wave, a clinical marker of sympathetic vascular tone, is modulated in part by calcium.
KW - Blood pressure oscillations
KW - Calcium
KW - Parathyroid hormone
KW - Power spectrum
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U2 - 10.1007/BF01845492
DO - 10.1007/BF01845492
M3 - Article
C2 - 7780291
AN - SCOPUS:0028910713
VL - 5
SP - 5
EP - 11
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
SN - 0959-9851
IS - 1
ER -