The effect of diphenylamine derivatives on arachidonic acid metabolism in rat peritoneal macrophages

Kazuo Ohuchi, Masako Watanabe, Yukari Fukui, Noriyasu Hirasawa, Tsuneo Ozeki, Susumu Tsurufuji

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of diphenylamine derivatives such as diclofenac sodium, mefenamic acid and lobenzarit disodium on arachidonic acid metabolism in rat peritoneal macrophages was examined. Lobenzarit disodium has no effect on prostaglandin E2 production as measured by radioimmunoassay although two other diphenylamine derivatives have a potent inhibito activity. Three diphenylamine derivatives have no effect on Ca2+ ionophore-stimulated release of radioactivity from (3H)arachidonic acid-labeled macrophages. HPLC analysis revealed that lobenzarit disodium had no effect on the synthesis of lipoxygenase products as observed in diclofenac sodium and mefenamic acid. It is concluded that lobenzarit disodium, although its fundamental chemical structure resembles diclofenac sodium and mefenamic acid, has no inhibitory activity on arachidonic acid metabolism, suggesting that immunomodulatory activities of lobenzarit disodium are manifested without interfering with arachidonic acid metabolism.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalProstaglandins, Leukotrienes and Medicine
Volume28
Issue number1
DOIs
Publication statusPublished - 1987 Jun

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology

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