The effect of dietary lipid hydroperoxide on lymphoid tissues in mice

Motoko Oarada, Emiko Ito, Kiyoshi Terao, Teruo Miyazawa, Kenshiro Fujimoto, Takashi Kaneda

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41 Citations (Scopus)


Effects of dietary lipid hydroperoxides on lymphoid tissue were studied in mice. When graded amounts (190, 270 and 310 mg) of methyl linoleate hydroperoxide (MLHPO) were orally administered to male C57BL/6 mice (6 weeks old), necrosis was observed in lymphocytes located among the reticular network in the thymus, and thymus weight was significantly decreased 24 h after the treatment. The spleen weight of mice given MLHPO tended to decrease. Spontaneous chemiluminescence of the thymus was remarkably increased after the dose. Thiobarbituric acid reactants in the liver, thymus and blood were also increased after the dose of MLHPO. At intervals of 3, 6, 12 and 24 h after a dose of 14-labeled MLHPO, 14 was detected in the blood and liver. Fatty infiltration of the liver was found after the treatment with MLHPO. These findings indicate that oral intake of lipid hydroperoxides causes significant damage to lymphoid tissues of mice.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Issue number2
Publication statusPublished - 1988 May 22


  • (Mouse)
  • Dietary lipid hydroperoxide
  • Lipid hydroperoxide
  • Lymphoid tissue
  • Methyl linoleate hydroperoxide

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology


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