TY - JOUR
T1 - The effect of dietary antioxidant supplementation in patients with glaucoma
AU - Himori, Noriko
AU - Yanagimachi, Maki Inoue
AU - Omodaka, Kazuko
AU - Shiga, Yukihiro
AU - Tsuda, Satoru
AU - Kunikata, Hiroshi
AU - Nakazawa, Toru
N1 - Funding Information:
The authors thank Mr. Tim Hilts for editing the language of the manuscript, and Ms. Ruriko Igarashi for providing excellent technical support with oxidative stress measurements. We thank Dr. Hisayo Kubota, Dr. Hideyo Kudo, Dr. Megumi Uematsu, Dr. Marika Sato, and Dr. Naoko Takada for their medical treatment support. We thank Orthmedico Inc. for analyzing the data. Author Contributions.
Funding Information:
Professor T oru Nakazawa reports grants from W akamoto Pharmaceutical Co., Ltd. during the conduct of this study; grants and personal fees from Santen Pharmaceutical Co., Ltd., Senju Pharmaceutical Co., Ltd., and T opcon Corporation, outside the submitted work; grants from Nidek Co., Ltd. This research was supported by W akamoto Pharmaceutical Co., Ltd. The authors report no other conflicts of interest in this work.
Publisher Copyright:
© 2021 Himori et al.
PY - 2021
Y1 - 2021
N2 - Purpose: Oxidative stress may be a risk factor for glaucoma, and many previous reports have suggested that antioxidants could be a promising treatment. Here, we investigated the effects of a novel supplement containing three food-derived antioxidants (hesperidin, crocetin, and Tamarindus indica) on markers of oxidative stress in patients with glaucoma. Patients and Methods: This study had a prospective, single arm design. Thirty Japanese glaucoma patients were recruited and given 4 tablets with ample water twice a day for 8 weeks. The treatment was stopped, and the subjects were followed for an additional 8 weeks. We measured biological antioxidant potential (BAP) with a free radical analyzer. We also measured urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG; a marker of oxidative DNA damage). Clinical laboratory data were measured in venous blood samples. Clinical parameters were also recorded. Comparisons used a one-way analysis of variance (ANOVA) followed by Dunnett’s test. Results: The 8-OHdG level was not reduced. We also divided the patients into groups with high or low oxidative stress. In patients with relatively high oxidative stress, the 8-OHdG level was significantly reduced at weeks 4, 8, 12, and 16 (P < 0.001, P < 0.01, P < 0.01, P < 0.01), and BAP was significantly elevated at weeks 8 and 12 (P = 0.03, P = 0.04). In patients with relatively low oxidative stress, the 8-OHdG level was not significantly reduced during supplement intake but was significantly elevated at weeks 12 and 16 (P =0.03, P = 0.04), while BAP was not significantly elevated. Conclusion: An 8-week oral course of antioxidant supplementation was effective in patients with a high oxidative stress level. Dietary supplementation could hold promise in the treatment of systemic oxidative stress-related diseases.
AB - Purpose: Oxidative stress may be a risk factor for glaucoma, and many previous reports have suggested that antioxidants could be a promising treatment. Here, we investigated the effects of a novel supplement containing three food-derived antioxidants (hesperidin, crocetin, and Tamarindus indica) on markers of oxidative stress in patients with glaucoma. Patients and Methods: This study had a prospective, single arm design. Thirty Japanese glaucoma patients were recruited and given 4 tablets with ample water twice a day for 8 weeks. The treatment was stopped, and the subjects were followed for an additional 8 weeks. We measured biological antioxidant potential (BAP) with a free radical analyzer. We also measured urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG; a marker of oxidative DNA damage). Clinical laboratory data were measured in venous blood samples. Clinical parameters were also recorded. Comparisons used a one-way analysis of variance (ANOVA) followed by Dunnett’s test. Results: The 8-OHdG level was not reduced. We also divided the patients into groups with high or low oxidative stress. In patients with relatively high oxidative stress, the 8-OHdG level was significantly reduced at weeks 4, 8, 12, and 16 (P < 0.001, P < 0.01, P < 0.01, P < 0.01), and BAP was significantly elevated at weeks 8 and 12 (P = 0.03, P = 0.04). In patients with relatively low oxidative stress, the 8-OHdG level was not significantly reduced during supplement intake but was significantly elevated at weeks 12 and 16 (P =0.03, P = 0.04), while BAP was not significantly elevated. Conclusion: An 8-week oral course of antioxidant supplementation was effective in patients with a high oxidative stress level. Dietary supplementation could hold promise in the treatment of systemic oxidative stress-related diseases.
KW - 8-OHdG
KW - Glaucoma
KW - Oxidative stress
KW - Supplement
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U2 - 10.2147/OPTH.S314288
DO - 10.2147/OPTH.S314288
M3 - Article
AN - SCOPUS:85108163992
VL - 15
SP - 2293
EP - 2300
JO - Clinical Ophthalmology
JF - Clinical Ophthalmology
SN - 1177-5467
ER -