The effect of cisplatin on kidney uptake of Technetium-99m-MDP in rats

T. Sato, S. Yoshioka, Y. Abe, J. Takahashi, K. Yamada, H. Fukuda, Y. Ogata, M. Tada, K. Kanao

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The following experiments were performed to study the effect of cisplatin on the uptake of 99mTC-MDP in kidneys. There is renal accumulation of 99mTc-MDP bone imaging agents in patients treated with cisplatin. Methods: Donryu rats weighing 150-160 g were administered 0.8 mg/kg of cisplatin intravenously for 7 days. On the day following the cisplatin injections and on the 37th day, we obtained 99mTc-MDP clearance from the blood and it showed two components: a fast and a slow component. Results: On both the first and 37th days, the fast component of the cisplatin-treated group was identical to the control rats. On the contrary, the slow component of the cisplatin-treated group and control rats was 393.6 ± 116.4 min and 85.2 ± 19.9 min, (p < 0.001), respectively. On the 37th day, the slow components in both groups were not significantly different. Technetium-99m-MDP bone scanning was performed on the first, 15th and 37th days following cisplatin administration. The scintigram on the first day showed high uptake 99mTc-MDp in kidneys, bones and liver. On the 15th day, relatively high uptake in kidneys was observed. However, on the 37th day, 99mTc-MDp uptake of the kidneys returned to normal. The binding rate of 99mTc-MDP and 99mTc-MDP with cisplatin were 99.4 ± 0.6% and 79.0 ± 4.6%, respectively. Conclusion: This study suggested that high renal uptake of 99mTc-MDP following administration of cisplatin was mainly due to delayed excretion of the radiopharmaceutical by binding with cisplatin.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalJournal of Nuclear Medicine Technology
Volume24
Issue number2
Publication statusPublished - 1996 Jan 1

Keywords

  • Binding rate
  • Bone scintigraphy
  • Cisplatin
  • Hot kidneys
  • Technetium-99m-MDP

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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