The effect of carbohydrate-restricted diets on the skin aging of mice

Ran Okouchi, Yuto Sakanoi, Tsuyoshi Tsuduki

Research output: Contribution to journalShort surveypeer-review

3 Citations (Scopus)


Low-carbohydrate, high-protein diets, known as carbohydrate-restricted diets, are in contrast to the carbohydrate-centric meals typical of the Japanese diet. Carbohydraterestricted diets were reported to reduce visceral fat, owing to which they have attracted attention and been widely implemented. If, as proposed, carbohydrate-restricted diets are effective in delaying senescence, then Japanese diets have a hidden potential to evolve further. However, long-term carbohydrate restriction in mice was reported to have a negative effect on the cardiovascular system, with shortening of lifespan due to activation of mechanistic target of rapamycin (mTOR). As a result, the safety of long-term adherence to carbohydraterestricted diets remains doubtful. Recently, we conducted a study using senescence-accelerated mouse-prone 8 (SAMP8) mice to examine the effects of a carbohydrate-restricted diet on aging and skin senescence, and to determine the effect of long-term carbohydrate restriction on the aging process in mice. Here, we discuss the safety of long-term carbohydrate restriction based on the findings obtained from animal studies.

Original languageEnglish
Pages (from-to)S67-S71
JournalJournal of nutritional science and vitaminology
Publication statusPublished - 2019


  • Carbohydrate restriction
  • Japanese diet
  • SAMP8
  • Senescence
  • Staple food

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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