TY - JOUR
T1 - The effect of Captopril on proteinuria in glomerular diseases
AU - Yamaguchi, Yuji
AU - Saito, Takao
AU - Obara, Katsuya
AU - Ootaka, Tetsuya
AU - Akiu, Naoki
AU - Sato, Hiroshi
AU - Kinoshita, Yasumichi
AU - Seino, Jin
AU - Tsunoda, Kazuo
AU - Yasujima, Minoru
AU - Abe, Keishi
AU - Yoshinaga, Kaoru
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1990/1
Y1 - 1990/1
N2 - We evaluated the efficacy of an ACE inhibitor Captopril (CAP) for the reduction of proteinuria in glomerular diseases, and tried to find the conditions in which urinary protein excretion was significantly decreased by this drug. Renin provocation test by CAP (C-test) was performed, and the result was compared to the effect on proteinuria. In 33 patients with proteinuria, ranging from 1.1 to 14.1g/day, CAP was administered. Urinary protein excretion was reduced from 3.6-0.6 to 2.8-0.4g/day (mean-SEM, p< 0.01) after 2 weeks. The decrease in urinary protein was significant when renal function was moderately impaired (30≦Ccr<60 ml/min) or patients were on a salt diet less than 7 g of NaCl daily. Reduction of urinary protein excretion by 2-week treatment of CAP was correlated with the result of C-test (r = 0.874, p<0.025). The long-term follow up for more than 6 months also suggested that CAP delayed the deterioration of renal function. Thus, CAP was proved effective in treating proteinuria, and C-test might give us an information of its proteinuria-suppressing effect in an individual case. But its efficacy was observed only in patients with moderately-reduced renal function or on low-salt diet. Therefore, we should select the cases carefully to expect the effect of CAP for the reduction of proteinuria.
AB - We evaluated the efficacy of an ACE inhibitor Captopril (CAP) for the reduction of proteinuria in glomerular diseases, and tried to find the conditions in which urinary protein excretion was significantly decreased by this drug. Renin provocation test by CAP (C-test) was performed, and the result was compared to the effect on proteinuria. In 33 patients with proteinuria, ranging from 1.1 to 14.1g/day, CAP was administered. Urinary protein excretion was reduced from 3.6-0.6 to 2.8-0.4g/day (mean-SEM, p< 0.01) after 2 weeks. The decrease in urinary protein was significant when renal function was moderately impaired (30≦Ccr<60 ml/min) or patients were on a salt diet less than 7 g of NaCl daily. Reduction of urinary protein excretion by 2-week treatment of CAP was correlated with the result of C-test (r = 0.874, p<0.025). The long-term follow up for more than 6 months also suggested that CAP delayed the deterioration of renal function. Thus, CAP was proved effective in treating proteinuria, and C-test might give us an information of its proteinuria-suppressing effect in an individual case. But its efficacy was observed only in patients with moderately-reduced renal function or on low-salt diet. Therefore, we should select the cases carefully to expect the effect of CAP for the reduction of proteinuria.
KW - Captopril
KW - glomerular diseases
KW - proteinuria
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U2 - 10.14842/jpnjnephrol1959.32.1009
DO - 10.14842/jpnjnephrol1959.32.1009
M3 - Article
C2 - 2263022
AN - SCOPUS:0025489824
VL - 32
SP - 1009
EP - 1016
JO - Japanese Journal of Nephrology
JF - Japanese Journal of Nephrology
SN - 0385-2385
IS - 9
ER -