TY - JOUR
T1 - The effect of captopril on heart rate in several types of hypertensive patients
AU - Imai, Y.
AU - Abe, K.
AU - Yoshinaga, K.
PY - 1981
Y1 - 1981
N2 - Captopril, an orally active converting enzyme inhibitor, was administered in a dose of 50 mg to 88 untreated hypertensives (70 essential hypertensives, 8 patients with renal arterial disease, 10 patients with renal parenchymal disease). Captopril caused a decrease in heart rate in 18 patients, but an increase in 2 patients. In the remaining 68, the heart rate did not change. As a whole, captopril caused a significant decrease in blood pressure without a compensatory increase in the heart rate. The change in heart rate caused by captopril in patients with renal arterial disease was significantly higher than that in essential hypertensives. A significant negative correlation was observed between the change in heart rate and plasma renin activity obtained immediately before captopril administration (n=79, r=-0.425, p<0.001).
AB - Captopril, an orally active converting enzyme inhibitor, was administered in a dose of 50 mg to 88 untreated hypertensives (70 essential hypertensives, 8 patients with renal arterial disease, 10 patients with renal parenchymal disease). Captopril caused a decrease in heart rate in 18 patients, but an increase in 2 patients. In the remaining 68, the heart rate did not change. As a whole, captopril caused a significant decrease in blood pressure without a compensatory increase in the heart rate. The change in heart rate caused by captopril in patients with renal arterial disease was significantly higher than that in essential hypertensives. A significant negative correlation was observed between the change in heart rate and plasma renin activity obtained immediately before captopril administration (n=79, r=-0.425, p<0.001).
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M3 - Article
C2 - 7022748
AN - SCOPUS:0019855731
VL - 133
SP - 243
EP - 244
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 2
ER -