The effect of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrin

H. Nikawa, L. P. Samaranayake, J. Tenovuo, Taizo Hamada

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effect of subminimal inhibitory concentrations (MICs) of nystatin, amphotericin B, clotrimazole, miconazole and 5-fluorocytosine on the in vitro susceptibility of Candida albicans to physiological concentrations of apo-lactoferrin was investigated. Pre-exposure of C. albicans in 1:4 and 1:16 MICs of the antifungals resulted in an increased resistance to apo-lactoferrin-mediated cell death. Preincubation of Candida in tunicamycin (an agent that inhibits the synthesis of yeast cell-wall mannoproteins) and subsequent exposure to apo-lactoferrin enhanced the antifungal activity, whilst addition of ergosterol (a yeast cell-wall component) to the assay suspension had no significant effect. These results taken together indicate that apo-lactoferrin, an important component of saliva, interacts with cell-membrane constituents of C. albicans such as mannoproteins, and may modulate the effect of topical antifungal agents commonly prescribed for oral candidoses.

Original languageEnglish
Pages (from-to)921-923
Number of pages3
JournalArchives of Oral Biology
Volume39
Issue number10
DOIs
Publication statusPublished - 1994 Jan 1

Keywords

  • Candida
  • antifungal agents
  • lactoferrin

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Fingerprint Dive into the research topics of 'The effect of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrin'. Together they form a unique fingerprint.

  • Cite this