The effect of a 50-Hz sinusoidal magnetic field on nitric oxide (NO) production by human umbilical vein endothelial cells (HUVECs)

Hidetake Miyata, Ken Ichi Ishizawa, Masami Ishido, Ken Sugawara, Masatoshi Murase, Tsuyoshi Hondou

Research output: Contribution to journalConference articlepeer-review

2 Citations (Scopus)

Abstract

To investigate the effect of magnetic fields on living systems, we analyzed the effect of a 50-Hz, 1-mT sinusoidal magnetic field on nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs). Statistically significant differences in NO production were identified between exposed and unexposed (sham) cells. This finding confirms previous studies showing that magnetic fields can influence NO production; however, unlike previous studies, our results demonstrate two-way deviation of NO production under the influence of a magnetic field. Thus, in some cases, NO production was higher for the exposed group than the sham group, while in other cases the reverse was true. We suggest that the magnetic field affected the homeostasis of NO levels in a complex manner. Thus, the resulting NO level was dependent on the condition of the cell in each experiment or cells in each experiment were at a different stage in the cell cycle and therefore exhibited a different response when exposed to the magnetic field.

Original languageEnglish
Article number012006
JournalJournal of Physics: Conference Series
Volume344
Issue number1
DOIs
Publication statusPublished - 2012
EventInternational and Interdisciplinary Workshop on Novel Phenomena in Integrated Complex Sciences: From Non-Living to Living Systems, IIW-NPICS 2010 - Kyoto, Japan
Duration: 2010 Oct 112010 Oct 14

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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