The Dmca1D channel mediates Ca2+ inward currents in Drosophila embryonic muscles

Yusuke Hara, Masayuki Koganezawa, Daisuke Yamamoto

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    We studied, in a genetic model organism, Drosophila melanogaster, the channel mechanisms underlying membrane excitation in the embryonic body wall muscle whose biophysical properties have been poorly characterized. The inward current underlying the action potential was solely mediated by a high-threshold class of voltage-gated Ca2+ channels, which exhibited slow inactivation, Ca2+ permeability with saturation at high [Ca2+]OUT, and sensitivity to a Ca2+ channel blocker, Cd2+. The Ca2+ current in the embryonic muscle was completely eliminated in Dmca1D mutants, indicating that the Dmca1D-encoded Ca2+ channel is the major mediator of inward currents in the body wall muscles throughout the embryonic and larval stages.

    Original languageEnglish
    Pages (from-to)117-123
    Number of pages7
    JournalJournal of neurogenetics
    Volume29
    Issue number2-3
    DOIs
    Publication statusPublished - 2015 Jul 3

    Keywords

    • Ca channel gating
    • Capermeability
    • mutants
    • skeletal muscle
    • whole-cell patch clamp relation

    ASJC Scopus subject areas

    • Genetics
    • Cellular and Molecular Neuroscience

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