The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: Pathological consideration of their potential roles

Naosuke Nonoguchi, Shin Ichi Miyatake, Motoi Fukumoto, Motomasa Furuse, Ryo Hiramatsu, Shinji Kawabata, Toshihiko Kuroiwa, Motomu Tsuji, Manabu Fukumoto, Koji Ono

Research output: Contribution to journalArticlepeer-review

107 Citations (Scopus)

Abstract

The cell type and localization of vascular endothelial growth factor (VEGF)-producing cells in human radiation necrosis (RN) are investigated from a histopathological and immunohistochemical standpoint using clinical specimens. Eighteen surgical specimens of symptomatic RN in the brain were retrospectively reviewed. These cases included different original histological tumor types and were treated with different radiation modalities. Histological analyses were performed using hematoxylin and eosin (H&E) staining, and anti-VEGF and anti-hypoxia-inducible factor (HIF)-1α immunohistochemistry. H&E staining showed marked angiogenesis and reactive astrocytosis at the perinecrotic area. The most prominent vasculature in this area was identified as telangiectasis. Immunohistochemistry indicated that HIF-1α was expressed predominantly in the perinecrotic area and that a large majority of VEGF-expressing cells were reactive astrocytes intensively distributed in this area. VEGF produced by the reactive astrocytes localized mainly in the perinecrotic area might be a major cause of both angiogenesis and the subsequent perilesional edema typically found in RN of the brain. The benefits of anti-VEGF antibody (bevacizumab) treatment in RN may be that VEGF secretion from the perinecrotic tissue is inhibited and that surgery would remove this tissue; both of these benefits result in effective reduction of edema associated with RN.

Original languageEnglish
Pages (from-to)423-431
Number of pages9
JournalJournal of Neuro-Oncology
Volume105
Issue number2
DOIs
Publication statusPublished - 2011 Nov

Keywords

  • Angiogenesis
  • Bevacizumab
  • Boron neutron capture therapy
  • Hypoxia-inducible factor-1α
  • Radiation necrosis
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Fingerprint

Dive into the research topics of 'The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: Pathological consideration of their potential roles'. Together they form a unique fingerprint.

Cite this