The distribution of dietary plant sterols in serum lipoproteins and liver subcellular fractions of rats

Michihiro Sugano, Hidekazu Morioka, Yoshitaka Kida, Ikuo Ikeda

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Rats were fed plant sterols containing campesterol and β-sitosterol in the different proportions, and their distribution in serum lipoproteins and in liver subcellular fractions was determined. In serum lipoproteins, the percentage as well as the concentration of plant sterols increased with the increase in the density of lipoproteins. Thus, high density lipoprotein (HDL) contained the highest and very low density lipoprotein (VLDL), the lowest. Also, there were distinct differences in the ratio of campesterol to sitosterol among lipoproteins, it was the highest in VLDL and lowest in HDL. Quantitatively, more than 75% of campesterol and 80% of sitosterol were carried in HDL; the values were significantly different from those of cholesterol (ca. 70%) in relation to total cholesterol. The distribution of plant sterols in liver subcellular fractions was virtually the same with that of cholesterol. Both nuclei and microsomes contained approximately 40% of total plant stetols.

Original languageEnglish
Pages (from-to)427-432
Number of pages6
JournalLipids
Volume13
Issue number6
DOIs
Publication statusPublished - 1978 Jun 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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