The distribution and origin of substance P-like immunoreactivity in the rat molar pulp and periodontal tissues

S. Wakisaka, S. Nishikawa, H. Ichikawa, S. Matsuo, Y. Takano, M. Akai

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)

Abstract

Rat mandibles were fixed in Zamboni fixative and demineralized in a mixture of EDTA and fixative. Substance P-like immunoreactivity was demonstrated by indirect immunofluorescence in molar pulp, periodontal ligament and gingiva. Substance P (SP) containing nerve fibres with varicosities were observed in the pulp horn and root pulp in general located around blood vessels. Some SP-containing fibres penetrated into the predentine and dentine. In the periodontal ligament, SP fibres were localized along the blood vessels in the middle and apical regions. Many SP-containing fibres were associated with the blood vessels in the lamina propria of gingiva. After inferior alveolar nerve section, SP-positive nerve fibres in the pulp and periodontal ligament disappeared completely. In gingiva the number of SP fibres decreased but not all fibres disappeared. Removal of the superior cervical ganglion did not affect the distribution of SP-containing nerve fibres.

Original languageEnglish
Pages (from-to)813-818
Number of pages6
JournalArchives of Oral Biology
Volume30
Issue number11-12
DOIs
Publication statusPublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

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