The distribution and origin of calcitonin gene-related peptide-containing nerve fibres in feline dental pulp - Relationship with substance P-containing nerve fibres

S. Wakisaka, H. Ichikawa, S. Nishikawa, S. Matsuo, Y. Takano, M. Akai

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

The origin and distribution of calcitonin gene-related peptide (CGRP)-like immunoreactivity in feline dental pulp were studied using indirect immunofluorescence. Nerve fibres with varicosities exhibiting CGRP-like immunoreactivity were observed to enter the pulp with blood vessels. Many CGRP-containing nerve fibres were found to extend along blood vessels in the central pulp, and some of these fibres exhibited a network arrangement in the walls of dental pulp blood vessels. However, some of fibres were apparently not associated with blood vessels. Some thin, CGRP-containing nerve fibres formed a part of the nerve plexus in the subodontoblastic area and penetrated into the odontoblastic layer. In animals that had undergone transection of the inferior alveolar nerve, no CGRP-containing nerve fibres were observed. Application of a double-immunofluorescence staining technique also revealed that the distribution of CGRP-containing nerve fibres is very similar to that of substance P-containing nerve fibres.

Original languageEnglish
Pages (from-to)585-589
Number of pages5
JournalHistochemistry
Volume86
Issue number6
DOIs
Publication statusPublished - 1987 Nov 1
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy
  • Agricultural and Biological Sciences(all)

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