The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi

Yohei Morishita, Huiping Zhang, Tohru Taniguchi, Keiji Mori, Teigo Asai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Heterologous expression of a unique biosynthetic gene cluster (BGC) comprising a highly reducing polyketide synthase and stand-alone thioesterase genes in Aspergillus oryzae enabled us to isolate a novel 34-membered polyene macrolide, phaeospelide A (1). This is the first isolation of a fungal polyene macrolide and the first demonstration of fungal aliphatic macrolide biosynthetic machinery. In addition, sequence similarity network analysis demonstrated the existence of a large number of BGCs for novel fungal macrolides.

Original languageEnglish
Pages (from-to)4788-4792
Number of pages5
JournalOrganic letters
Volume21
Issue number12
DOIs
Publication statusPublished - 2019 Jun 21
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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