The design of molecular sensing interfaces with lipid-bilayer assemblies

Ayumi Hirano, Michio Niwano, Masao Sugawara

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

We describe the current status of techniques for preparing planar lipid bilayers, the fusion of sensory elements and the design of bilayer interfaces for analytical applications. Advances in bilayer fabrication have allowed preparation of lipid bilayers with membrane resistance of >1 GΩ ("gigaseal") in flow, microfluidic and array formats, which have enabled single-channel and multi-channel recording. Not only biological but also engineered channels have been adopted as sensory elements for lipid-bilayer-based biosensors. Synthetic and inorganic channels are also emerging for designing membranes for lipid-bilayer sensors. We discuss the potential of lipid bilayers containing biological, engineered or synthetic channels for the design of biosensors, including drug-screening biosensors.

Original languageEnglish
Pages (from-to)512-520
Number of pages9
JournalTrAC - Trends in Analytical Chemistry
Volume27
Issue number6
DOIs
Publication statusPublished - 2008 Jun 1

Keywords

  • Biological ion channel
  • Biosensor
  • Drug-screening biosensor
  • Engineered channel
  • Inorganic channel
  • Lipid bilayer
  • Membrane
  • Synthetic channel

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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