The degree of hepatic regeneration after partial hepatectomy in rats with peritonitis and the role of lipid peroxidation

Kenji Fukuhara, Masanori Suzuki, Michiaki Unno, Mohammad Masihur Rahman, Kojin Endo, Seiki Matsuno

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Bile accumulation in the peritoneal cavity after partial hepatectomy reduces hepatic regeneration. In 70% of hepatectomized rats with bile peritonitis, hepatic DNA synthesis showed a delayed initiation and diminished peak level. Because intraperitoneal bile significantly accelerated lipid peroxidation and decreased energy metabolism in the liver remnant, all hepatectomized rats with bile peritonitis died within 7 days. Subcutaneous administration of exogenous combined antioxidants SOD and catalase dramatically reduced lipid peroxidation and improved the survival rate. Although the slightly elevated serum endotoxin level in rats with peritonitis may play a role in the inhibition of hepatic regeneration, the result suggest that intraperitoneal accumulation of bile components may also directly accelerate lipid peroxidation in the liver remnant, inhibiting the hepatic regeneration.

Original languageEnglish
Pages (from-to)881-886
Number of pages6
JournalFree Radical Biology and Medicine
Volume26
Issue number7-8
DOIs
Publication statusPublished - 1999 Apr 1

Keywords

  • Free radicals
  • Hepatic resection
  • Lipid peroxidation
  • Liver failure
  • Peritonitis

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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