Abstract
A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose. A Val/Ile codon difference in the primary structure of the CYP1A1 protein (Val-, Ile-type) was in linkage disequilibrium with the Msp I RFLP. A synergistic increase in susceptibility to lung cancer was found when combining genotyping of CYP1A1 and the Mu-class of glutathione S-transferase (GST1). Interindividual variability in the genetic make-up of carcinogen metabolizing enzymes may thus be a key host factor to explain the differences in susceptibility to chemical carcinogenesis among individuals.
Original language | English |
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Pages (from-to) | 77-87 |
Number of pages | 11 |
Journal | Critical Reviews in Oncology and Hematology |
Volume | 14 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1993 Feb |
Externally published | Yes |
ASJC Scopus subject areas
- Hematology
- Oncology