The CYP1A1 gene and cancer susceptibility

K. name Kawajiri; K. i. Nakachi; K. zue Imai; Junko Watanabe; Shin ichi Hayashi

doi:10.1016/1040-8428(93)90007-Q

The CYP1A1 gene and cancer susceptibility

K. name Kawajiri, K. i. Nakachi, K. zue Imai, Junko Watanabe, Shin ichi Hayashi

Research output: Contribution to journal › Review article › peer-review

231 Citations (Scopus)

Abstract

A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose. A Val/Ile codon difference in the primary structure of the CYP1A1 protein (Val-, Ile-type) was in linkage disequilibrium with the Msp I RFLP. A synergistic increase in susceptibility to lung cancer was found when combining genotyping of CYP1A1 and the Mu-class of glutathione S-transferase (GST1). Interindividual variability in the genetic make-up of carcinogen metabolizing enzymes may thus be a key host factor to explain the differences in susceptibility to chemical carcinogenesis among individuals.

Original language	English
Pages (from-to)	77-87
Number of pages	11
Journal	Critical Reviews in Oncology and Hematology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/1040-8428(93)90007-Q
Publication status	Published - 1993 Feb
Externally published	Yes

ASJC Scopus subject areas

Hematology
Oncology

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title = "The CYP1A1 gene and cancer susceptibility",

abstract = "A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose. A Val/Ile codon difference in the primary structure of the CYP1A1 protein (Val-, Ile-type) was in linkage disequilibrium with the Msp I RFLP. A synergistic increase in susceptibility to lung cancer was found when combining genotyping of CYP1A1 and the Mu-class of glutathione S-transferase (GST1). Interindividual variability in the genetic make-up of carcinogen metabolizing enzymes may thus be a key host factor to explain the differences in susceptibility to chemical carcinogenesis among individuals.",

author = "Kawajiri, {K. name} and Nakachi, {K. i.} and Imai, {K. zue} and Junko Watanabe and Hayashi, {Shin ichi}",

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AU - Kawajiri, K. name

AU - Nakachi, K. i.

AU - Imai, K. zue

AU - Watanabe, Junko

AU - Hayashi, Shin ichi

PY - 1993/2

Y1 - 1993/2

N2 - A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose. A Val/Ile codon difference in the primary structure of the CYP1A1 protein (Val-, Ile-type) was in linkage disequilibrium with the Msp I RFLP. A synergistic increase in susceptibility to lung cancer was found when combining genotyping of CYP1A1 and the Mu-class of glutathione S-transferase (GST1). Interindividual variability in the genetic make-up of carcinogen metabolizing enzymes may thus be a key host factor to explain the differences in susceptibility to chemical carcinogenesis among individuals.

AB - A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose. A Val/Ile codon difference in the primary structure of the CYP1A1 protein (Val-, Ile-type) was in linkage disequilibrium with the Msp I RFLP. A synergistic increase in susceptibility to lung cancer was found when combining genotyping of CYP1A1 and the Mu-class of glutathione S-transferase (GST1). Interindividual variability in the genetic make-up of carcinogen metabolizing enzymes may thus be a key host factor to explain the differences in susceptibility to chemical carcinogenesis among individuals.

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