The CYP1A1 gene and cancer susceptibility

K. name Kawajiri, K. i. Nakachi, K. zue Imai, Junko Watanabe, Shin ichi Hayashi

Research output: Contribution to journalReview articlepeer-review

232 Citations (Scopus)

Abstract

A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose. A Val/Ile codon difference in the primary structure of the CYP1A1 protein (Val-, Ile-type) was in linkage disequilibrium with the Msp I RFLP. A synergistic increase in susceptibility to lung cancer was found when combining genotyping of CYP1A1 and the Mu-class of glutathione S-transferase (GST1). Interindividual variability in the genetic make-up of carcinogen metabolizing enzymes may thus be a key host factor to explain the differences in susceptibility to chemical carcinogenesis among individuals.

Original languageEnglish
Pages (from-to)77-87
Number of pages11
JournalCritical Reviews in Oncology and Hematology
Volume14
Issue number1
DOIs
Publication statusPublished - 1993 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology

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