The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone

Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Kunio Hirata, Yuki Shiimura, Dohyun Im, Tatsuro Shimamura, Norimichi Nomura, Hiroko Iwanari, Takao Hamakubo, Osamu Kusano-Arai, Hiromi Hisano, Tomoko Uemura, Chiyo Suno, Junken Aoki, So Iwata

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Asada et al. determined the structure of angiotensin II type 2 receptor (AT2R) bound with endogenous peptide hormone, angiotensin II. The structure reveals important features of the angiotensin peptide for the receptor activation, which provides us a molecular basis to understand the physiological role of this peptide hormone.

Original languageEnglish
Pages (from-to)418-425.e4
JournalStructure
Volume28
Issue number4
DOIs
Publication statusPublished - 2020 Apr 7

Keywords

  • G protein coupled receptor
  • X-ray crystal structure
  • angiotensin receptor
  • peptide hormon

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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  • Cite this

    Asada, H., Inoue, A., Ngako Kadji, F. M., Hirata, K., Shiimura, Y., Im, D., Shimamura, T., Nomura, N., Iwanari, H., Hamakubo, T., Kusano-Arai, O., Hisano, H., Uemura, T., Suno, C., Aoki, J., & Iwata, S. (2020). The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone. Structure, 28(4), 418-425.e4. https://doi.org/10.1016/j.str.2019.12.003