The correlation between the immunohistochemical expression of DF3 antigen and serum CA15-3 in breast cancer patients

Noriaki Ohuchi, Shin ichi Sato, Minoru Akimoto, Yukio Taira, Naoya Matoba, Kenji Takahashi, Shozo Mori

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The immunohistochemical expression of DF3 antigen and serum concentrations of CA15-3, a breast carcinoma-associated antigen recognized by the monoclonal antibodies (MAbs) 115D8 and DF3, was investigated in breast cancer patients. The levels of serum CA15-3 in 23 primary breast cancer patients did not correlate to the percentage cytoplasmic reactivity of MAb DF3 with the carcinoma cells in tissue specimens from each respective patients. In 17 patients who subsequently developed metastatic breast cancer, however, the serum CA15-3 concentrations generally correlated well to the cytoplasmic reactivity of MAb DF3 with the carcinoma cells in specimens obtained at initial biopsy or mastectomy. Elevated levels of serum CA15-3 were seen in metastatic breast cancer patients when the carcinoma cells in their primary specimens expressed enhanced levels of cytoplasmic DF3 antigen. The results of this study suggest that the immunohistochemical demonstration of DF3 antigen in tissue specimens, together with the periodical measurement of circulating CA15-3 antigen, may be important for monitoring the clinical course of breast cancer patients.

Original languageEnglish
Pages (from-to)129-137
Number of pages9
JournalThe Japanese Journal of Surgery
Volume21
Issue number2
DOIs
Publication statusPublished - 1991 Mar

Keywords

  • breast carcinoma
  • immunohistochemistry
  • monoclonal antibody
  • tumor associated antigen

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'The correlation between the immunohistochemical expression of DF3 antigen and serum CA15-3 in breast cancer patients'. Together they form a unique fingerprint.

Cite this