The correlation between body mass index and breast cancer risk or estrogen receptor status in Okinawan women

Kentaro Tamaki, Nobumitsu Tamaki, Shigeharu Terukina, Yoshihiko Kamada, Kano Uehara, Miwa Arakaki, Minoru Miyashita, Takanori Ishida, Keely May Mcnamara, Noriaki Ohuchi, Hironobu Sasano

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Dietary changes resulting from the post-World War II occupation of Okinawa by the US military have been largely deleterious, resulting in a marked increase of obesity among Okinawan residents. In this study, we examined the association between BMI and the risk of developing breast cancer according to the menstruation status and age, and the correlation between BMI and expression of estrogen receptor (ER). Breast cancer cases were 3,431 females without any personal or family history of breast cancer. Control subjects were 5,575 women drawn from the clinical files of Nahanishi Clinic. We found that women, who were overweight or obese, regardless of menopausal stage, had a higher risk of breast cancer compared to women with normal weight and this difference was statistically significant (p < 0.001, respectively). This risk was especially apparent in older (> 40 years) overweight or obese women. The women who were overweight or obese during postmenopausal ages were at higher risk of ER-positive breast cancer compared to women with normal weight. Results of our present study clearly indicate that increased BMI was associated with increased risk of developing breast cancer in Okinawan women, regardless of menopausal status. In addition, there was statistically significant correlation between BMI and ER expression in the postmenopausal period. Given the obesity epidemic associated with the extreme sociological and dietary changes brought about by the post-war occupation of Okinawa, the present study provides essential guidelines on the management, treatment and future breast cancer risk in Okinawa.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalTohoku Journal of Experimental Medicine
Volume234
Issue number3
DOIs
Publication statusPublished - 2014 Oct 3

Keywords

  • Body mass index
  • Breast cancer risk
  • Estrogen receptor
  • Menstruation status
  • Obesity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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