The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies

Yamagata University Genomic Cohort Consortium

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The impact of cryptic relatedness (CR) on genomic association studies is well studied and known to inflate false-positive rates as reported by several groups. In contrast, conventional epidemiological studies for environmental risks, the confounding effect of CR is still uninvestigated. In this study, we investigated the confounding effect of unadjusted CR among a rural cohort in the relationship between environmental risk factors (body mass index, smoking status, alcohol consumption) and systolic blood pressure. We applied the methods of population-based whole-genome association studies for the analysis of the genome-wide single nucleotide polymorphism data in 1622 subjects, and detected 20.2% CR in this cohort population. In the case of the sample size, approximately 1000, the ratio of CR to the population was 20.2%, the population prevalence 25%, the prevalence in the CR 26%, heritability for liability 14.3% and prevalence in the subpopulation without CR 26%, the difference of estimated regression coefficient between samples with and without CR was not significant (P-value = 0.55). On the other hand, in another case with approximately >20% heritability for liability, we showed that confounding due to CR biased the estimation of exposure effects.

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalMolecular Genetics and Genomic Medicine
Volume1
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Confounding effect
  • Cryptic relatedness
  • Systolic blood pressure

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies'. Together they form a unique fingerprint.

  • Cite this