The component changes of lysophospholipid mediators in colorectal cancer

Chieko Kitamura, Hirofumi Sonoda, Hiroaki Nozawa, Kuniyuki Kano, Shigenobu Emoto, Koji Murono, Manabu Kaneko, Masaya Hiyoshi, Kazuhito Sasaki, Takeshi Nishikawa, Yasutaka Shuno, Toshiaki Tanaka, Keisuke Hata, Kazushige Kawai, Junken Aoki, Soichiro Ishihara

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Although lysophospholipids are known to play an important role in the development and progression of several kinds of cancers, their role in human colorectal cancer is as yet unclear. In this study, we aim to investigate lysophospholipid levels in colorectal cancer tissues to identify lysophospholipids, the levels of which change specifically in colorectal cancers. We used liquid chromatography–tandem mass spectrometry to measure lysophospholipid levels in cancerous and normal tissues from 11 surgical specimens of sigmoid colon cancers, since recent advances in this field have improved detection sensitivities for lysophospholipids. Our results indicate that, in colon cancer tissues, levels of lysophosphatidylinositol and lysophosphatidylserine were significantly higher (p = 0.025 and p = 0.01, respectively), whereas levels of lysophosphatidic acid were significantly lower (p = 0.0019) than in normal tissues. Although levels of lysophosphatidylglycerol were higher in colon cancer tissues than in normal tissues, this difference was not found to be significant (p = 0.11). Fatty acid analysis further showed that 18:0 lysophosphatidylinositol and 18:0 lysophosphatidylserine were the predominant species of lysophospholipids in colon cancer tissues. These components may be potentially involved in colorectal carcinogenesis.

Original languageEnglish
JournalTumor Biology
Issue number5
Publication statusPublished - 2019 May 1


  • Lysophospholipid
  • colon cancer
  • lipidomics
  • liquid chromatography–tandem mass spectrometry
  • lysophosphatidylinositol

ASJC Scopus subject areas

  • Cancer Research


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