The coexistence of Alzheimer's disease and Creutzfeldt-Jakob disease in a patient with dementia of long duration

T. Muramoto, T. Kitamoto, H. Koga, J. Tateishi

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40 Citations (Scopus)

Abstract

We report here a 75-year-old-male with a slowly progressive dementia of 5-year duration along with a rapid exacerbation of symptoms in the terminal 3 months. Neuropathological examinations revealed findings consistent with conspicuous Alzheimer's disease and mild Creutzfeldt-Jakob disease (CJD). The plaque amyloid was exclusively composed of β-protein. The immunohistochemistry of prion protein using hydrolytic autoclaving pretreatment showed diffuse gray matter stainings in the sections of both the cerebral and cerebellar cortices. This method was thus considered useful in confirming the diagnosis of CJD for this case.

Original languageEnglish
Pages (from-to)686-689
Number of pages4
JournalActa neuropathologica
Volume84
Issue number6
DOIs
Publication statusPublished - 1992 Nov 1
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Creutzfeldt-Jakob disease
  • Immunohistochemistry
  • Prion protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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