The coexistence of Alzheimer's disease and Creutzfeldt-Jakob disease in a patient with dementia of long duration

T. Muramoto; T. Kitamoto; H. Koga; J. Tateishi

doi:10.1007/BF00227747

The coexistence of Alzheimer's disease and Creutzfeldt-Jakob disease in a patient with dementia of long duration

T. Muramoto, T. Kitamoto, H. Koga, J. Tateishi

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

We report here a 75-year-old-male with a slowly progressive dementia of 5-year duration along with a rapid exacerbation of symptoms in the terminal 3 months. Neuropathological examinations revealed findings consistent with conspicuous Alzheimer's disease and mild Creutzfeldt-Jakob disease (CJD). The plaque amyloid was exclusively composed of β-protein. The immunohistochemistry of prion protein using hydrolytic autoclaving pretreatment showed diffuse gray matter stainings in the sections of both the cerebral and cerebellar cortices. This method was thus considered useful in confirming the diagnosis of CJD for this case.

Original language	English
Pages (from-to)	686-689
Number of pages	4
Journal	Acta neuropathologica
Volume	84
Issue number	6
DOIs	https://doi.org/10.1007/BF00227747
Publication status	Published - 1992 Nov 1
Externally published	Yes

Keywords

Alzheimer's disease
Creutzfeldt-Jakob disease
Immunohistochemistry
Prion protein

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1007/BF00227747

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AU - Tateishi, J.

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