The co-expression of VR1 and VRL-1 in the rat vagal sensory ganglia

H. Ichikawa, T. Sugimoto

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Immunohistochemistry for two nociceptive transducers, the vanilloid receptor 1 (VR1) and vanilloid receptor 1-like receptor (VRL-1), was performed on the vagal sensory ganglia. In the jugular ganglion, VR1-immunoreactive (IR) neurons were small to medium-sized (range 49.7-1125.6 μm2, mean±S.D. 407.7±219.7 μm2), whereas VRL-1-IR neurons were medium-sized to large (range 223.6-1341.1 μm2, mean±S.D. 584.3±253.5 μm2). In the nodose ganglion, VR1- and VRL-1-IR neurons were mostly small to medium-sized (VR1: range 148.5-1464.4 μm2, mean±S.D. 554.3±207.4 μm2; VRL-1: range 161.7-1166.2 μm2, mean±S.D. 541.9±186.2 μm2). The double immunofluorescence method revealed that co-expression of VR1-immunoreactivity among VRL-1-IR neurons was more abundant in the nodose ganglion (63%) than in the jugular ganglion (4%). The present study suggests that co-expression of VR1 and VRL-1 may be more common in visceral sensory neurons than in somatic sensory neurons.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalBrain research
Volume980
Issue number2
DOIs
Publication statusPublished - 2003 Aug 8
Externally publishedYes

Keywords

  • Cell size
  • Immunohistochemistry
  • Jugular ganglion
  • Nodose ganglion
  • Vanilloid receptor 1
  • Vanilloid receptor 1-like receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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