The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis

Toshio Miyata, Junji Takeda, Yoshiyasu Iida, Norio Yamada, Norimitsu Inoue, Minoru Takahashi, Kenji Maeda, Teruo Kitani, Taroh Kinoshita

Research output: Contribution to journalArticlepeer-review

408 Citations (Scopus)

Abstract

The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of the core of the GPI anchor is conserved in protozoa and mammals and so is its biosynthetic pathway. A complementary DNA encoding a human protein termed PIG-A (phosphatidylinositol glycan-class A) was cloned. PIG-A was necessary for synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.

Original languageEnglish
Pages (from-to)1318-1320
Number of pages3
JournalScience
Volume259
Issue number5099
DOIs
Publication statusPublished - 1993 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • General

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