The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients

Sasitorn Siritho, Douglas K. Sato, Kimihiko Kaneko, Kazuo Fujihara, Naraporn Prayoonwiwat

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Background: Myelin oligodendrocyte glycoprotein (anti-MOG) antibody was reported in anti-aquaporin-4 (anti-AQP4) seronegative neuromyelitis optica spectrum disorders (NMOSD) patients. Objectives: To describe clinical phenotypes associated with anti-MOG. Methods: Seventy consecutive Thai patients with inflammatory idiopathic demyelinating central nervous system disorders (IIDCD) who were previously anti-AQP4 seronegative were tested for anti-MOG. Results: Anti-MOG was positive in six patients, representing 20.7% of the IIDCD anti-AQP4 seronegative patients with a non-multiple sclerosis phenotype, and most had relapses. All first presented with optic neuritis with good visual recovery after treatment. Conclusions: Anti-MOG positive patients may have manifestations that mimic NMOSD but differ in their course and prognosis from anti-AQP4 positive NMOSD.

Original languageEnglish
Pages (from-to)964-968
Number of pages5
JournalMultiple Sclerosis
Volume22
Issue number7
DOIs
Publication statusPublished - 2016 Jun 1

Keywords

  • Biomarkers
  • epidemiology
  • neuromyelitis optica (NMO)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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