TY - JOUR
T1 - The clinical applicability of albuminuria testing in Japanese hypertensive patients
T2 - The AVA-E study
AU - Tani, Yoshihiro
AU - Nakayama, Masaaki
AU - Kanno, Makoto
AU - Kimura, Hiroshi
AU - Watanabe, Kimio
AU - Tanaka, Kenichi
AU - Hayashi, Yoshimitsu
AU - Asahi, Koichi
AU - Iseki, Kunitoshi
AU - Watanabe, Tsuyoshi
PY - 2013/2/21
Y1 - 2013/2/21
N2 - Objective Albuminuria is thought to reflect generalized endothelial dysfunction. In hypertensive patients, albuminuria increases the risk of cardiovascular disease (CVD) events. Therefore, screening for albuminuria is critical for stratifying risks in hypertensive patients. However, a limited number of Japanese studies have performed quantitative examinations of albuminuria. The objective of this study was to examine the utility of the CLINITEK MICROALB CREATININE TEST for albuminuria screening. Materials The CLINITEK MICROALB CREATININE TEST consists of a urine test strip that assesses al-bumin excretion corrected for the urine creatinine levels in only 60 seconds without the need for any special facilities. The CLINITEK MICROALB CREATININE TEST was performed in 5, 647 Japanese hypertensive patients, excluding diabetic patients, and the clinical significance of the test was evaluated. Results According to the CLINITEK MICROALB CREATININE TEST, the A1 (albumin creatinine ratio: ACR <30 mg/g · creatinine), A2 (ACR 30-299 mg/g · creatinine) and A3 (ACR? 300 mg/g · creatinine) levels of albuminuria were present in 61.2%, 32.5% and 6.3% of the patients surveyed, respectively. The proportions of A2 and A3 patients increased with chronic kidney disease (CKD) stage, blood pressure, age and previous history of CVD. According to a multivariate logistic regression analysis, the A2 and A3 levels of albuminuria were found to be independently associated with a previous history of CVD (odds ratio: 1.36, 95% confidence interval: 1.08-1.72, p<0.01) after adjusting for age, diabetes, blood pressure and estimated glomerular filtra-tion rate (eGFR). Conclusion In hypertensive patients, the A2 and A3 levels of albuminuria on the CLINITEK MICROALB CREATININE TEST are associated with a previous history of CVD, independent of eGFR. Therefore, by re-flecting the status of systemic vascular injury, this test may help to perform CVD risk stratification.
AB - Objective Albuminuria is thought to reflect generalized endothelial dysfunction. In hypertensive patients, albuminuria increases the risk of cardiovascular disease (CVD) events. Therefore, screening for albuminuria is critical for stratifying risks in hypertensive patients. However, a limited number of Japanese studies have performed quantitative examinations of albuminuria. The objective of this study was to examine the utility of the CLINITEK MICROALB CREATININE TEST for albuminuria screening. Materials The CLINITEK MICROALB CREATININE TEST consists of a urine test strip that assesses al-bumin excretion corrected for the urine creatinine levels in only 60 seconds without the need for any special facilities. The CLINITEK MICROALB CREATININE TEST was performed in 5, 647 Japanese hypertensive patients, excluding diabetic patients, and the clinical significance of the test was evaluated. Results According to the CLINITEK MICROALB CREATININE TEST, the A1 (albumin creatinine ratio: ACR <30 mg/g · creatinine), A2 (ACR 30-299 mg/g · creatinine) and A3 (ACR? 300 mg/g · creatinine) levels of albuminuria were present in 61.2%, 32.5% and 6.3% of the patients surveyed, respectively. The proportions of A2 and A3 patients increased with chronic kidney disease (CKD) stage, blood pressure, age and previous history of CVD. According to a multivariate logistic regression analysis, the A2 and A3 levels of albuminuria were found to be independently associated with a previous history of CVD (odds ratio: 1.36, 95% confidence interval: 1.08-1.72, p<0.01) after adjusting for age, diabetes, blood pressure and estimated glomerular filtra-tion rate (eGFR). Conclusion In hypertensive patients, the A2 and A3 levels of albuminuria on the CLINITEK MICROALB CREATININE TEST are associated with a previous history of CVD, independent of eGFR. Therefore, by re-flecting the status of systemic vascular injury, this test may help to perform CVD risk stratification.
KW - Albuminuria
KW - CLINITEK MICROALB CREATININE TEST
KW - Hypertension
KW - Risk factors
KW - Screening test
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U2 - 10.2169/internalmedicine.52.8854
DO - 10.2169/internalmedicine.52.8854
M3 - Article
C2 - 23411696
AN - SCOPUS:84873952656
VL - 52
SP - 425
EP - 430
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 4
ER -