The Circadian Variation of Blood Pressure and Heart Rate in Patients with Hyperthyroidism

Naoyoshi Minami, Yutaka Imai, Keishi Abe, Masanori Munakata, Toshio Sakurada, Makiko Yamamoto, Katsumi Yoshida, Kaoru Yoshinaga, Hiroshi Sekino

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Minami, N., Imai, Y., Abe, K., Munakata, M., Sakurada, T., Yamamoto, M., Yoshida, K., Sekino, H. and Yoshinaga, K. The Circadian Variation of Blood Pressure and Heart Rate in Patients with Hyperthyroidism. Tohoku J. Exp. Med., 1989, 159 (3), 185-193-The circadian variation of blood pressure (BP) and heart rate (HR) was examined in 18 normal subjects, 15 patients with essential hypertension treated with β-blockers and 21 patients with hyperthyroidism. Most of the patients with hyperthyroidism were also treated with β-blockers. The 24 hr BP was measured with an ambulatory blood pressure monitoring device (UBP-100) every 5min. A nocturnal fall in BP and HR was observed in the patients with essential hypertension treated with β-blockers and the patients with mild to moderate hyperthyroidism as well as normal subjects. On the other hand, in patients with severe hyperthyroidism the nocturnal fall was observed in HR alone, and the fall was small in its amplitude. There was a significant negative correlation between triiodothyronine (T3) level and percentage amplitude of the nocturnal fall in systolic BP (n=21, r=-0.5, p<0.01). However, this relation was not significant in diastolic BP and HR. These results indicate that excess thyroid hormone may modulate the circadian variation of BP and HR.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
Journalthe tohoku journal of experimental medicine
Volume159
Issue number3
DOIs
Publication statusPublished - 1989
Externally publishedYes

Keywords

  • ambulatory blood pressure monitoring
  • circadian rhythm
  • heart rate
  • hyperthyroidism
  • triiodothyronine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Minami, N., Imai, Y., Abe, K., Munakata, M., Sakurada, T., Yamamoto, M., Yoshida, K., Yoshinaga, K., & Sekino, H. (1989). The Circadian Variation of Blood Pressure and Heart Rate in Patients with Hyperthyroidism. the tohoku journal of experimental medicine, 159(3), 185-193. https://doi.org/10.1620/tjem.159.185