The Changes in Active and Inactive Renin Induced by Various Maneuvers in Hypertensive Patients

Toshikazu Goto, Keishi Abe, Kazuo Tsunoda, Masahide Seino, Minoru Yasujima, Yutaka Imai, Satoru Chiba, Makito Sato, Toshiaki Haruyama, Ken Omata, Ko Sato, Jiro Tajima, Masaya Tanno, Kei Kudo, Kaoru Yoshinaga

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The changes in active and inactive renin after captopril (n = 29) or furosemide administration (n = 10) were studied in hypertensive patients. Furthermore, after percutaneous transluminal angioplasty (PTA) in 3 cases of renovascular hypertension (RVH), and after nephrectomy in a case of juxtaglomerular cell tumor, the time course of the changes in these two types of renin was investigated. Inactive renin was activated by trypsin treatment. Plasma renin concentration was measured by using an excess of sheep substrate. In patients with essential hypertension or primary aldosteronism, inactive renin was unchanged, irrespective of response in active renin, after the administration of captopril and furosemide. In patients with RVH, inactive renin was markedly decreased by furosemide but unchanged by captopril, in spite of significant increase in active renin. After PTA and nephrectomy, incative renin decreased slower than active renin. These data support the idea that in patients with RVH, the increase in active renin by furosemide is at least partly due to the activation of inactive renin. It is also suggested that the increase in active renin by captopril is mainly due to the promoted release of active renin from the kidney. Furthermore, it seems likely that the metabolic clearance of inactive renin is slower than that in active renin.

Original languageEnglish
Pages (from-to)169-181
Number of pages13
Journalthe tohoku journal of experimental medicine
Volume149
Issue number2
DOIs
Publication statusPublished - 1986
Externally publishedYes

Keywords

  • captopril
  • furosemide
  • inactive renin
  • juxtaglomerular cell tumor
  • percutaneous transluminal angioplasty

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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