The change of periapical exudate prostaglandin E2 levels during root canal treatment

Hidetoshi Shimauchi

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18 Citations (Scopus)


We have previously demonstrated that detectable levels of prostaglandin E2 exist in periapical exudates (PE-PGE2) from root canals of periapical periodontitis. Our data from a cross-sectional study also suggested the association of PE-PGE2 concentrations with the active phase of periapical lesions. The objective of this study was to investigate the longitudinal changes of PE-PGE2 levels during root canal treatment. Periapical exudate specimens were quantitatively sampled from root canals of 20 nonvital teeth at consecutive treatment visits to measure PGE2 concentrations. The mean PE-PGE2 levels significantly decreased following the endodontic therapy (158.0 ± 54.1 pg/μl in the first samples versus 48.4 ± 37.9 pg/μl in the second samples). A significant correlation was also found between the changes in PE-PGE2 levels and the clinical disease expression of periapical periodontitis (p < 0.01). Decreased PGE2 production is considered to reflect the remission of disease activity. These results suggest the central roles of PGE2 in regulatory mechanisms for the expression of periapical disease.

Original languageEnglish
Pages (from-to)755-758
Number of pages4
JournalJournal of endodontics
Issue number12
Publication statusPublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Dentistry(all)


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