TY - JOUR
T1 - The change of periapical exudate prostaglandin E2 levels during root canal treatment
AU - Shimauchi, Hidetoshi
PY - 1997
Y1 - 1997
N2 - We have previously demonstrated that detectable levels of prostaglandin E2 exist in periapical exudates (PE-PGE2) from root canals of periapical periodontitis. Our data from a cross-sectional study also suggested the association of PE-PGE2 concentrations with the active phase of periapical lesions. The objective of this study was to investigate the longitudinal changes of PE-PGE2 levels during root canal treatment. Periapical exudate specimens were quantitatively sampled from root canals of 20 nonvital teeth at consecutive treatment visits to measure PGE2 concentrations. The mean PE-PGE2 levels significantly decreased following the endodontic therapy (158.0 ± 54.1 pg/μl in the first samples versus 48.4 ± 37.9 pg/μl in the second samples). A significant correlation was also found between the changes in PE-PGE2 levels and the clinical disease expression of periapical periodontitis (p < 0.01). Decreased PGE2 production is considered to reflect the remission of disease activity. These results suggest the central roles of PGE2 in regulatory mechanisms for the expression of periapical disease.
AB - We have previously demonstrated that detectable levels of prostaglandin E2 exist in periapical exudates (PE-PGE2) from root canals of periapical periodontitis. Our data from a cross-sectional study also suggested the association of PE-PGE2 concentrations with the active phase of periapical lesions. The objective of this study was to investigate the longitudinal changes of PE-PGE2 levels during root canal treatment. Periapical exudate specimens were quantitatively sampled from root canals of 20 nonvital teeth at consecutive treatment visits to measure PGE2 concentrations. The mean PE-PGE2 levels significantly decreased following the endodontic therapy (158.0 ± 54.1 pg/μl in the first samples versus 48.4 ± 37.9 pg/μl in the second samples). A significant correlation was also found between the changes in PE-PGE2 levels and the clinical disease expression of periapical periodontitis (p < 0.01). Decreased PGE2 production is considered to reflect the remission of disease activity. These results suggest the central roles of PGE2 in regulatory mechanisms for the expression of periapical disease.
UR - http://www.scopus.com/inward/record.url?scp=0031296836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031296836&partnerID=8YFLogxK
U2 - 10.1016/S0099-2399(97)80350-0
DO - 10.1016/S0099-2399(97)80350-0
M3 - Article
C2 - 9487853
AN - SCOPUS:0031296836
VL - 23
SP - 755
EP - 758
JO - Journal of Endodontics
JF - Journal of Endodontics
SN - 0099-2399
IS - 12
ER -