The change in conjugated linoleic acid concentration in blood of Japanese fed a conjugated linoleic acid diet

Kenta Sato, Nahoko Shinohara, Taro Honma, Junya Ito, Tatsuya Arai, Naohisa Nosaka, Toshiaki Aoyama, Tsuyoshi Tsuduki, Ikuo Ikeda

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Conjugated linoleic acid (CLA) is a collective term used for fatty acids with a conjugated double bond that are geometrical and positional isomers of linoleic acid. Antiobesity and anti-cancer properties, an immunopotentiation effect, and promotion of bone formation by CLA have been shown in cell culture and animal studies. A mixture of 9c11tand 10t12c-CLA is now used as a health food supplement after testing in clinical trials. These trials focused on improvement of lipid metabolism by CLA, whereas few studies have examined absorption and metabolism of CLA in humans. In addition, there is no report concerning absorption and metabolism of CLA in Japanese. This study was designed to examine CLA concentration in blood, the elimination rate of CLA, and metabolic differences between 9c11t-CLA and 10t12c-CLA in blood in Japanese who ingested CLA (about 2 g/d, equal weights of 9c11t-CLA and 10t12c-CLA) for 3 wk. Blood samples were collected 1 wk before the 3-wk period, on the first and last days of the period, and 1 wk after the end of the period, and the CLA concentration and distribution in blood were investigated. The CLA concentration in blood was significantly increased by CLA ingestion and reached 36 μ mol/L. The CLA concentration in blood one week after the intake period was significantly lower than that at the end of CLA intake. The 10t12c-CLA level in plasma decreased faster than that of 9c11t-CLA. This suggests faster metabolism (fatty acid β oxidation) of 10t12c-CLA compared with 9c11t-CLA.

Original languageEnglish
Pages (from-to)364-371
Number of pages8
JournalJournal of nutritional science and vitaminology
Issue number5
Publication statusPublished - 2011 Feb 1


  • CLA
  • Conjugated fatty acid
  • Conjugated linoleic acid
  • Human
  • Metabolism

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


Dive into the research topics of 'The change in conjugated linoleic acid concentration in blood of Japanese fed a conjugated linoleic acid diet'. Together they form a unique fingerprint.

Cite this