The CFTA method: A reliable procedure for the determination of the absolute configuration of chiral primary amines by 1H NMR spectroscopic analysis

Yoshio Takeuchi, Masaru Segawa, Hidehito Fujisawa, Kenji Omata, Siegfried N. Lodwig, Clifford J. Unkefer

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Surprisingly stable anti-periplanar conformers of CFTA amides form the basis of a new and very reliable method for determining the absolute configuration of chiral primary amines by 1H NMR spectroscopy (see picture). CFTA = α-cyano-α-fluoro-p-tolylacetic acid. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)4617-4619
Number of pages3
JournalAngewandte Chemie - International Edition
Volume45
Issue number28
DOIs
Publication statusPublished - 2006 Jul 10

Keywords

  • CFTA diastereomers
  • Configuration determination
  • NMR spectroscopy
  • Reactivity

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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