TY - JOUR
T1 - The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension
AU - Watanabe, Takuya
AU - Arai, Yoichi
AU - Mitsui, Yuki
AU - Kusaura, Tatsuya
AU - Okawa, Wataru
AU - Kajihara, Yasushi
AU - Saito, Ikuo
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Chlorogenic acids (CGA) in green coffee bean extract (GCE) reduce blood pressure in spontaneously hypertensive rats and humans. The authors examined the blood pressure-lowering effect and safety of CGA in patients with mild hypertension through a placebo-controlled, randomized clinical trial. Subjects (n=28) were randomized to receive treatment with CGA (140 mg/day) from GCE or placebo. Blood pressure, pulse rate, body mass index, routine blood test, hematochemistry, urinalysis, and subjective symptoms were recorded throughout the study. In the CGA group, but not the placebo group, blood pressure (systolic and diastolic) decreased significantly during the ingestion period. There was no difference in body mass index and pulse rate between groups, nor were there any apparent side effects. Thus, CGA from GCE is effective in decreasing blood pressure and safe for patients with mild hypertension.
AB - Chlorogenic acids (CGA) in green coffee bean extract (GCE) reduce blood pressure in spontaneously hypertensive rats and humans. The authors examined the blood pressure-lowering effect and safety of CGA in patients with mild hypertension through a placebo-controlled, randomized clinical trial. Subjects (n=28) were randomized to receive treatment with CGA (140 mg/day) from GCE or placebo. Blood pressure, pulse rate, body mass index, routine blood test, hematochemistry, urinalysis, and subjective symptoms were recorded throughout the study. In the CGA group, but not the placebo group, blood pressure (systolic and diastolic) decreased significantly during the ingestion period. There was no difference in body mass index and pulse rate between groups, nor were there any apparent side effects. Thus, CGA from GCE is effective in decreasing blood pressure and safe for patients with mild hypertension.
KW - Blood pressure
KW - Chlorogenic acid
KW - Clinical trial
KW - Functional foods
KW - Green coffee beans
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U2 - 10.1080/10641960600798655
DO - 10.1080/10641960600798655
M3 - Article
C2 - 16820341
AN - SCOPUS:33745868733
VL - 28
SP - 439
EP - 449
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
SN - 1064-1963
IS - 5
ER -