The biodegradability of poly(Pro-Hyp-Gly) synthetic polypeptide and the promotion of a dermal wound epithelialization using a poly(Pro-Hyp-Gly) sponge

Masao Tanihara, Kazumi Kajiwara, Keiko Ida, Yoshihisa Suzuki, Masanobu Kamitakahara, Shin Ichi Ogata

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Collagens are widely used in medical applications, but animal-derived collagens have several drawbacks, such as low thermal stability, nonspecific cell attachment, and susceptibility to contamination by infectious pathogens, such as prions, which may transfect humans. We have previously reported the chemical synthesis of polypeptides consisting of a Pro-Hyp-Gly sequence and the high thermostability of their triple-helical structure. To clarify the biomaterial characteristics of the poly(Pro-Hyp-Gly) polypeptide, we assessed its biodegradability and its capability for skin regeneration. Eight weeks after implantation, a poly(Pro-Hyp-Gly) freeze-dried sponge embedded subcutaneously into a rat dorsal area degraded at the same rate as Terudermis*, which is made from bovine type I atelocollagen and is used as an artificial dermis. Surprisingly, compared with Terudermis, the poly(Pro-Hyp-Gly) sponge significantly promoted epithelialization of a full-thickness wound on a rabbit's ear pad. This chemically synthesized polypeptide may be useful as a scaffold for tissue engineering and tissue regeneration.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalJournal of Biomedical Materials Research - Part A
Volume85
Issue number1
DOIs
Publication statusPublished - 2008 Apr 1
Externally publishedYes

Keywords

  • Biodegradability
  • Epithelialization
  • Poly(Pro-Hyp-Gly)
  • Synthetic polypeptide
  • Wound repair

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Fingerprint Dive into the research topics of 'The biodegradability of poly(Pro-Hyp-Gly) synthetic polypeptide and the promotion of a dermal wound epithelialization using a poly(Pro-Hyp-Gly) sponge'. Together they form a unique fingerprint.

  • Cite this