The axon as a unique computational unit in neurons

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)


In the mammalian cortex, axons are highly ramified and link an enormous number of neurons over large distances. The conventional view assumes that action potentials (APs) are initiated at the axon initial segment in an all-or-none fashion and are then self-propagated orthodromically along axon collaterals without distortion of the AP waveform. By contrast, recent experimental results suggest that the axonal AP waveform can be modified depending on the activation states of the ion channels and receptors on axonal cell membranes. This AP modulation can regulate neurotransmission to postsynaptic neurons. In addition, the latest studies have provided evidence that cortical axons can integrate somatic burst firings and promote activity-dependent ectopic AP generation, which may underlie the oscillogenesis of fast rhythmic network activity. These seminal observations indicate that axons can perform diverse functional operations that extend beyond the prevailing model of axon physiology.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalNeuroscience Research
Issue number2
Publication statusPublished - 2013 Feb
Externally publishedYes


  • Action potential
  • Axon
  • Calcium
  • Depolarization
  • Oscillation
  • Synaptic transmission

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'The axon as a unique computational unit in neurons'. Together they form a unique fingerprint.

Cite this