The ASK1-MAP kinase pathways in immune and stress responses

Teruyuki Hayakawa, Atsushi Matsuzawa, Takuya Noguchi, Kohsuke Takeda, Hidenori Ichijo

Research output: Contribution to journalShort surveypeer-review

75 Citations (Scopus)

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.

Original languageEnglish
Pages (from-to)1098-1107
Number of pages10
JournalMicrobes and Infection
Volume8
Issue number4
DOIs
Publication statusPublished - 2006 Apr 1
Externally publishedYes

Keywords

  • Apoptosis signal-regulating kinase 1
  • Inflammation
  • Innate immunity
  • MAP kinase cascades
  • Oxidative stresses

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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