The anorectic effect of neurotensin is mediated via a histamine H 1 receptor in mice

Kousaku Ohinata, Tomoko Shimano, Rena Yamauchi, Shinobu Sakurada, Kazuhiko Yanai, Masaaki Yoshikawa

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Neurotensin (NT), a tridecapeptide found in the mammalian brain and peripheral tissues, induces a decrease in food intake after central administration. In this investigation, we examine whether the histaminergic system is involved in NT-induced suppression of feeding. Intracerebroventricular injection of NT (0.1-1 nmol/mouse) led to dose-dependent inhibition of food intake in fasted ddY mice. The anorectic effect induced by NT (0.1 nmol/mouse) was ameliorated upon co-administration of pyrilamine (3 nmol/mouse), an antagonist for histomine H 1 receptor. The NT-induced anorectic effect was partially ameliorated in H 1 knockout mice. The findings suggest that the H 1 receptor in part mediates the NT-induced suppression of food intake.

Original languageEnglish
Pages (from-to)2135-2138
Number of pages4
JournalPeptides
Volume25
Issue number12
DOIs
Publication statusPublished - 2004 Dec 1

Keywords

  • Food intake
  • H receptor
  • Histamine
  • Leptin
  • Neurotensin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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