The analysis of surgical lung biopsy and explanted lung specimens sheds light on the pathological progression of chronic bird-related hypersensitivity pneumonitis

Satoshi Hanzawa, Tomoya Tateishi, Tamiko Takemura, Yoshinori Okada, Yoshihito Yamada, Masafumi Noda, Yasunari Miyazaki, Naohiko Inase

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Chronic hypersensitivity pneumonitis is an interstitial pneumonia caused by an immunological reaction to the chronic inhalation of an antigen. Little is known, however, about the pathological change of the pulmonary lesions. A 33-year-old man was diagnosed with chronic bird-related hypersensitivity pneumonitis based on the findings of a surgical lung biopsy and an inhalation provocation test. He underwent lung transplantation at 8 years after the diagnosis because of disease progression. We conclude that the analysis of the explant suggests that the presence of extensive fibrosis in the centrilobular and perilobular area with bridging fibrosis is a form of pathological progression of chronic hypersensitivity pneumonitis.

Original languageEnglish
Pages (from-to)1145-1150
Number of pages6
JournalInternal Medicine
Volume58
Issue number8
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Bridging fibrosis
  • Centrilobular fibrosis
  • Chronic hypersensitivity pneumonitis
  • Lung transplantation
  • Subpleural and paraseptal fibrosis

ASJC Scopus subject areas

  • Internal Medicine

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