The amount and pattern of DNA polymorphism under the neutral mutation hypothesis

Fumio Tajima, Kazuharu Misawa, Hideki Innan

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The amount and pattern of DNA polymorphism can give useful information on the maintenance mechanism of genetic variation at the DNA level. In this note we have shown the amount and pattern of DNA polymorphism expected under the neutral theory. The amount of DNA polymorphism can be estimated from the average number of nucleotide differences per site, the proportion of segregating sites, and so on. We have shown how to estimate 0 from these quantities, where Θ = 4Nv, N is the effective population size and v is the mutation rate per site per generation. We have also shown the expectations of the nucleotide variation within and between allelic classes.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalGenetica
Volume102-103
DOIs
Publication statusPublished - 1998

Keywords

  • DNA polymorphism
  • Finite site model
  • Heterogeneity of mutation rate
  • Infinite site model
  • Neutral theory

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics
  • Plant Science
  • Insect Science

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