TY - JOUR
T1 - The Adjuvant Effect of Squalene, an Active Ingredient of Functional Foods, on Doxorubicin-Treated Allograft Mice
AU - Narayan Bhilwade, Hari
AU - Tatewaki, Naoto
AU - Konishi, Tetsuya
AU - Nishida, Miyako
AU - Eitsuka, Takahiro
AU - Yasui, Hironobu
AU - Inanami, Osamu
AU - Handa, Osamu
AU - Naito, Yuji
AU - Ikekawa, Nobuo
AU - Nishida, Hiroshi
N1 - Funding Information:
This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 24580203 to HN; Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (MEXT)-Supported Program for the Strategic Research Foundation at Private Universities Grant Number S1001030 to HN and TK. We thank Nissei Marine Industrial Co., Ltd. for their support of this study by supplying SQ. We also thank Dr. Deepak Sharma from Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India for critically going through the manuscript.
Funding Information:
This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 24580203 to HN; Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (MEXT)-Supported Program for the Strategic Research Foundation at Private Universities Grant Number S1001030 to HN and TK.
Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
PY - 2019
Y1 - 2019
N2 - Many functional foods or physiologically active ingredients derived from plants and animals are actively being investigated for their role in chronic disease prevention. Squalene (SQ) is found as active ingredient in the functional foods predominantly present in olive oil and shark liver oil. It is known that during chemotherapy anticancer drugs induce inflammation. SQ has been thought to prevent and suppress inflammation; however, there is little direct evidence available. We examined the adjuvant effect of SQ on tumor-transplanted mice along with anticancer drug doxorubicin (DOX). SQ significantly suppressed the DOX-induced increase in prostaglandin E2 (PGE2) concentration (P < 0.05) in plasma of tumor-bearing mice. SQ inhibited the numbers of writhing response (P < 0.05), formalin-induced pain and decreased COX-2 and substance P expression in the tumor tissue compared to control mice and also enhanced the antitumor efficacy of DOX in allograft mice. Thus, SQ reduces inflammation through modulation of PGE2 production indicating its potential as an adjuvant during chemotherapy in tumor-bearing mice.
AB - Many functional foods or physiologically active ingredients derived from plants and animals are actively being investigated for their role in chronic disease prevention. Squalene (SQ) is found as active ingredient in the functional foods predominantly present in olive oil and shark liver oil. It is known that during chemotherapy anticancer drugs induce inflammation. SQ has been thought to prevent and suppress inflammation; however, there is little direct evidence available. We examined the adjuvant effect of SQ on tumor-transplanted mice along with anticancer drug doxorubicin (DOX). SQ significantly suppressed the DOX-induced increase in prostaglandin E2 (PGE2) concentration (P < 0.05) in plasma of tumor-bearing mice. SQ inhibited the numbers of writhing response (P < 0.05), formalin-induced pain and decreased COX-2 and substance P expression in the tumor tissue compared to control mice and also enhanced the antitumor efficacy of DOX in allograft mice. Thus, SQ reduces inflammation through modulation of PGE2 production indicating its potential as an adjuvant during chemotherapy in tumor-bearing mice.
UR - http://www.scopus.com/inward/record.url?scp=85067647484&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067647484&partnerID=8YFLogxK
U2 - 10.1080/01635581.2019.1597900
DO - 10.1080/01635581.2019.1597900
M3 - Article
C2 - 31179755
AN - SCOPUS:85067647484
VL - 71
SP - 1153
EP - 1164
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 7
ER -
